Rongoā Haumaru Āpirini
Ingoa hua
HWTS-MG050-Kete Kimi Rongoā Haumaru Āpipirini (PCR Whakapūngao)
Te mate urutā
Ko te Āpirini, he rongoā whai hua hei ārai i te kohikohinga pereti toto, e whakamahia whānuitia ana hei ārai me te rongoā i ngā mate pūnaha toto me ngā mate roro. E kitea ana i roto i te rangahau kāore ētahi tūroro e kaha ki te aukati i te mahi a ngā pereti toto ahakoa te whakamahinga roa o te āpirini iti-horopeta, arā, te ātete ki te āpirini (AR). Ko te tere he tata ki te 50%-60%, ā, he mārama ngā rerekētanga iwi. He mahi nui tā te Glycoprotein IIb/IIIa (GPI IIb/IIIa) i roto i te kohikohinga pereti toto me te thrombosis ohorere i ngā wāhi whara o te pūnaha toto. Kua whakaatuhia e ngā rangahau he mahi nui tā ngā momo ira i roto i te ātete ki te āpirini, ko te arotahi nui ko ngā momo ira GPIIIa P1A1/A2, PEAR1 me PTGS1. Ko te GPIIIa P1A2 te ira matua mō te ātete ki te āpirini. Ka whakarerekē ngā whakarerekētanga ira i roto i tēnei ira i te hanganga o ngā kaiwhakawhiwhi GPIIb/IIIa, ka hua ake he hononga whakawhiti i waenga i ngā pereti toto me te kohikohinga pereti toto. I kitea i roto i te rangahau he nui ake te auau o ngā ira P1A2 i roto i ngā tūroro ātete-āpipirini i tērā o ngā tūroro tairongo-āpipirini, ā, he iti te whai huatanga o ngā tūroro he ira P1A2/A2 homozygous i muri i te tango i te āpipirini. Ko ngā tūroro he ira P1A2 mutant e whiwhi ana i te stenting he auau mate toto iti iho i te 5 ngā wā i tērā o ngā tūroro momo-mohoao homozygous P1A1, me te hiahia kia nui ake ngā horopeta o te āpipirini kia tutuki ai ngā pānga anticoagulant. He pai te urupare a te ira PEAR1 GG ki te āpipirini, ā, ko ngā tūroro he ira AA, AG rānei e tango ana i te āpipirini (e honoa ana rānei ki te clopidogrel) i muri i te whakaurunga o te stent he nui te mate myocardial me te mate. He nui te mōrearea o te ira PTGS1 GG ki te ātete ki te āpipirini (HR: 10) me te nui o ngā mate cardiovascular (HR: 2.55). He iti te mōrearea o te ira AG, ā, me aro nui ki te pānga o te maimoatanga āpipirini. He tairongo ake te ira AA ki te āpipirini, ā, he iti noa te auau o ngā mate cardiovascular. Ko ngā hua kitenga o tēnei hua e tohu ana i ngā hua kitenga o ngā ira tangata PEAR1, PTGS1, me GPIIIa.
Ngā Tawhā Hangarau
| Rokiroki | ≤-18℃ |
| Te roa o te oranga | 12 marama |
| Momo Tauira | Te ūkui korokoro |
| CV | ≤5.0% |
| LoD | 1.0ng/μL |
| Ngā Taputapu e Pā Ana | E pā ana ki te matū kimi momo I: Ngā Pūnaha Koiora Whakamahia 7500 Ngā Pūnaha PCR Wā-Tūturu, QuantStudio®5 Ngā Pūnaha PCR Wā-Tūturu, Ngā Pūnaha PCR Wā-Tūturu SLAN-96P (Hongshi Medical Technology Co., Ltd.), Ngā Pūnaha Kitenga PCR Wā-Tūturu LineGene 9600 Plus (FQD-96A, hangarau Hangzhou Bioer), MA-6000 Pūrere Huringa Wera Tau-Tūturu (Suzhou Molarray Co., Ltd.), Pūnaha PCR Wā-Tūturu BioRad CFX96, Pūnaha PCR Wā-Tūturu BioRad CFX Opus 96. E pā ana ki te matū kimi momo II: ŪtemonaTMAIO800 (HWTS-EQ007) nā Jiangsu Macro & Micro-Test Med-Tech Co., Ltd. |
Rere Mahi
Mīhini Tango Waikawa Karihi Aunoa Whakamātautau-Iti (HWTS-3006C, HWTS-3006B)) nā Jiangsu Macro & Micro-Test Med-Tech Co., Ltd.
Ko te rōrahi o te tauira i tangohia he 200μL, ā, ko te rōrahi wairewa i tūtohutia he 100μL.
