Te Paturopi o te Clostridium Difficile Glutamate Dehydrogenase (GDH) me te Paitini A/B

Ko te Clostridium difficile (CD) he bacillus gram-positive anaerobic obligate, he tipu noa i roto i te tinana tangata. Ka āraia te whakatipu o ētahi atu tipu nā te nui o ngā paturopi e whakamahia ana, ā, ka whakaputa uri te CD i roto i te tinana tangata i roto i ngā rahinga nui. Ka wehea te CD ki ngā momo whakaputa paitini me ngā momo kore-paitini. Ka whakaputa ngā momo CD katoa i te glutamate dehydrogenase (GDH) ina whakaputa uri ana, ā, ko ngā momo toxigenic anake he pathogenic. Ka taea e ngā momo whakaputa paitini te whakaputa i ngā paitini e rua, A me B. Ko te Toxigenic A he enterotoxin, ka taea te mumura o te pakitara whekau, te urunga pūtau, te pikinga o te urunga o te pakitara whekau, te toto me te necrosis. Ko te Toxigenic B he cytotoxin, e kino ana i te cytoskeleton, e puta ai te pyknosis pūtau me te necrosis, ā, e kino tika ana i ngā pūtau parietal whekau, ka hua ake te mate korere me te pseudomembranous colitis.