Ia tau i te 17 o Paenga-whāwhā ko te Rā Matepukupuku o te Ao.
01 Tirohanga Whānui mō te Mate Pukupuku o te Ao
I ngā tau tata nei, i te pikinga tonu o te oranga o te tangata me te pēhanga hinengaro, kei te piki haere hoki te maha o ngā pukupuku i ia tau, i ia tau.
Kua noho ko ngā pukupuku kino (matepukupuku) hei tētahi o ngā raruraru hauora tūmatanui nui e tino mōrearea ana ki te hauora o te taupori Haina. E ai ki ngā raraunga tatauranga hou, ko te matenga o ngā pukupuku kino te 23.91% o ngā take katoa o te mate i waenga i ngā kainoho, ā, kua piki haere tonu te maha me te matenga o ngā pukupuku kino i roto i ngā tau tekau kua pahure ake nei. Engari ehara te matepukupuku i te tikanga he "whiu mate." I mārama te tohu a te World Health Organization mēnā ka kitea wawe, ka taea te whakaora i te 60%-90% o ngā matepukupuku! Ko te hautoru o ngā matepukupuku ka taea te ārai, ko te hautoru o ngā matepukupuku ka taea te whakaora, ā, ko te hautoru o ngā matepukupuku ka taea te rongoā hei whakaroa i te ora.
02 He aha te pukupuku
Ko te puku e pā ana ki te rauropi hou i hangaia e te tipu haere o ngā pūtau kiko ā-rohe i raro i te mahi a ngā momo āhuatanga pukupuku. Kua kitea e ngā rangahau he rerekē ngā huringa pākia o ngā pūtau puku i ngā pūtau noa. I taua wā anō, ka taea e ngā pūtau puku te urutau ki ngā huringa o te taiao pākia mā te whakawhiti i waenga i te glycolysis me te oxidative phosphorylation.
03 Te Whakaora Matepukupuku Whaiaro
Ko te maimoatanga mate pukupuku takitahi e ahu mai ana i ngā mōhiohio tātaritanga o ngā ira ūnga o te mate me ngā hua o ngā rangahau hauora e ahu mai ana i ngā taunakitanga. Mā tēnei ka whakaratohia he pūtake mō ngā tūroro ki te whiwhi i te mahere maimoatanga tika, kua noho hei ia o te whanaketanga hauora hou. Kua whakaūhia e ngā rangahau haumanu mā te kimi i te whakarerekētanga ira o ngā tohu koiora, te momo ira SNP, te āhua o te ira me tōna whakaaturanga pūmua i roto i ngā tauira koiora o ngā tūroro pukupuku hei matapae i te whai huatanga o te rongoā me te aromatawai i te matapae, me te ārahi i te maimoatanga haumanu takitahi, ka taea te whakapai ake i te whai huatanga me te whakaiti i ngā pānga kino, hei whakatairanga i te whakamahinga tika o ngā rauemi hauora.
E toru ngā momo matua o te whakamātautau ngota mō te mate pukupuku: te tātaritanga, te tuku iho, me te rongoā. Ko te whakamātautau rongoā te kaupapa matua o te mea e kiia nei ko te "pathology rongoā" me te rongoā whaiaro, ā, he maha ake ngā paturopi me ngā aukati ngota iti ka taea te aro ki ngā ira matua me ngā ara tohu motuhake ki te pukupuku ka taea te whakamahi ki te rongoā i ngā pukupuku.
Ko te rongoā arotahi ngota o ngā pukupuku e aro ana ki ngā ngota tohu o ngā pūtau pukupuku, ā, ka uru atu ki te tukanga o ngā pūtau matepukupuku. Ko tōna pānga nui ki ngā pūtau pukupuku, engari he iti noa te pānga ki ngā pūtau noa. Ka taea te whakamahi i ngā kaiwhakawhiwhi ira tipu pukupuku, ngā ngota whakawhiti tohu, ngā pūmua huringa pūtau, ngā kaiwhakahaere apoptosis, ngā whākōkī proteolytic, te ira tipu endothelial vascular, me ētahi atu hei ūnga ngota mō te rongoā pukupuku. I te 28 o Tīhema, 2020, i whakamāramahia e te "Ngā Mahi Whakahaere mō te Whakamahinga Hauora o ngā Rongoā Antineoplastic (Whakamātautau)" i whakaputaina e te National Health and Medical Commission: Mō ngā rongoā he ūnga ira mārama, me whai i te mātāpono o te whakamahi i a rātou i muri i te whakamātautau ira ūnga.
04 Whakamātautau ira e aro ana ki te pukupuku
He maha ngā momo whakarerekētanga ira i roto i ngā pukupuku, ā, he rerekē ngā momo whakarerekētanga ira e whakamahi ana i ngā rongoā kua tohua. Mā te whakamārama i te momo whakarerekētanga ira me te whiriwhiri tika i te rongoā kua tohua ka whai hua ngā tūroro. I whakamahia ngā tikanga kimi ira hei kimi i te rerekētanga o ngā ira e pā ana ki ngā rongoā kua tohua i roto i ngā pukupuku. Mā te tātari i te pānga o ngā rerekētanga ira ki te whai huatanga o te rongoā, ka taea e tātou te āwhina i ngā tākuta ki te whakawhanake i te mahere maimoatanga takitahi tino tika.
05 Otinga
Kua whakawhanakehia e Macro & Micro-Test he raupapa kete kimi mō te kimi ira pukupuku, e whakarato ana i te otinga whānui mō te rongoā e aro ana ki te pukupuku.
Kete Kimi Ira Hurihanga 29 o te Ira EGFR Tangata (PCR Whakapūngao Hikoi)
E whakamahia ana tēnei kete hei kimi i ngā whakarerekētanga ira i roto i ngā tauira 18-21 o te ira EGFR i roto i ngā tauira mai i ngā tūroro matepukupuku pūkahukahu ehara i te pūtau iti.
1. Ka whakauruhia e te pūnaha te mana whakahaere kounga tohutoro ā-roto, ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga o te whakamātautau.
2. Te aro nui: Mā te kitenga o te otinga tauhohenga waikawa karihi ka taea te kite pūmau i te tere whakarerekētanga o te 1% i raro i te papamuri o te 3ng/μL momo mohoao.
3. Te tino motuhaketanga: Kāore he tauhohenga whakawhiti ki te DNA ira tangata momo-tūroa me ētahi atu momo ira whakarerekē.
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Kete Kimi Ira Hurihanga KRAS 8 (PCR Whakapūtanga Hiko)
Ko te kaupapa o tēnei kete he kimi i ngā whakarerekētanga ira e 8 i roto i ngā kōtona 12 me te 13 o te ira K-ras i roto i te DNA i tangohia mai i ngā wāhanga mate tangata kua whakauruhia ki te paraffin.
1. Ka whakauruhia e te pūnaha te mana whakahaere kounga tohutoro ā-roto, ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga o te whakamātautau.
2. Te aro nui: Mā te kitenga o te otinga tauhohenga waikawa karihi ka taea te kite pūmau i te tere whakarerekētanga o te 1% i raro i te papamuri o te 3ng/μL momo mohoao.
3. Te tino motuhaketanga: Kāore he tauhohenga whakawhiti ki te DNA ira tangata momo-tūroa me ētahi atu momo ira whakarerekē.
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Kete Kimi Whakarerekētanga Ira EML4-ALK Tangata (PCR Whakapūtanga)
E whakamahia ana tēnei kete hei kimi i ngā momo whakarerekētanga 12 o te ira whakakotahitanga EML4-ALK i roto i ngā tauira o ngā tūroro matepukupuku pūkahukahu tangata ehara i te pūtau iti i roto i te vitro.
1. Ka whakauruhia e te pūnaha te mana whakahaere kounga tohutoro ā-roto, ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga o te whakamātautau.
2. Te aro nui: Ka taea e tēnei kete te kite i ngā whakarerekētanga hanumi tae noa ki te 20 tārua.
3. Te tino motuhaketanga: Kāore he tauhohenga whakawhiti ki te DNA ira tangata momo-tūroa me ētahi atu momo ira whakarerekē.
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Kete Kimi Whakarerekētanga Ira ROS1 Tangata (PCR Whakapūtanga)
E whakamahia ana tēnei kete hei kimi i ngā momo whakarerekētanga ira ROS1 e 14 i roto i ngā tauira mate pukupuku pūkahukahu tangata ehara i te pūtau iti.
1. Ka whakauruhia e te pūnaha te mana whakahaere kounga tohutoro ā-roto, ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga o te whakamātautau.
2. Te aro nui: Ka taea e tēnei kete te kite i ngā whakarerekētanga hanumi tae noa ki te 20 tārua.
3. Te tino motuhaketanga: Kāore he tauhohenga whakawhiti ki te DNA ira tangata momo-tūroa me ētahi atu momo ira whakarerekē.
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Kete Kimi Whakarerekētanga Ira Tangata BRAF V600E (PCR Whakapūtanga Hiko)
E whakamahia ana tēnei kete whakamātautau hei kimi i te whakarerekētanga ira BRAF V600E i roto i ngā tauira kiko kua whakauruhia ki te paraffin o te melanoma tangata, te mate pukupuku colorectal, te mate pukupuku tairoi me te mate pukupuku pūkahukahu in vitro.
1. Ka whakauruhia e te pūnaha te mana whakahaere kounga tohutoro ā-roto, ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga o te whakamātautau.
2. Te aro nui: Mā te kitenga o te otinga tauhohenga waikawa karihi ka taea te kite pūmau i te tere whakarerekētanga o te 1% i raro i te papamuri o te 3ng/μL momo mohoao.
3. Te tino motuhaketanga: Kāore he tauhohenga whakawhiti ki te DNA ira tangata momo-tūroa me ētahi atu momo ira whakarerekē.
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| Tau o te Putumōhio | Ingoa Hua | Whakatakotoranga |
| HWTS-TM012A/B | Kete Kimi Ira Tangata EGFR 29 (PCR Fluorescence) | 16 whakamātautau/kete, 32 whakamātautau/kete |
| HWTS-TM014A/B | Kete Kitenga Huringa KRAS 8 (PCR Whakapūtanga Hiko) | 24 whakamātautau/kete，48 whakamātautau/kete |
| HWTS-TM006A/B | Kete Kimi Ira Whakakotahitanga EML4-ALK Tangata (PCR Whakapūtanga) | 20 whakamātautau/kete，50 whakamātautau/kete |
| HWTS-TM009A/B | Kete Kimi Whakarerekētanga Ira ROS1 Tangata (PCR Whakapūtanga) | 20 whakamātautau/kete，50 whakamātautau/kete |
| HWTS-TM007A/B | Kete Kimi Whakarerekētanga Ira Tangata BRAF V600E (PCR Whakapūtanga Hiko) | 24 whakamātautau/kete，48 whakamātautau/kete |
| HWTS-GE010A | Kete Kimi Whakarerekētanga Ira Whakakotahi BCR-ABL Tangata (PCR Whakapūtanga) | 24 ngā whakamātautau/kete |
Wā tuku: 17 Paenga-whāwhā 2023