Ko te mate pūkahukahu myelogenous mau tonu (CML) he mate kino o ngā pūtau take hematopoietic. Neke atu i te 95% o ngā tūroro CML kei roto i ō rātou pūtau toto te chromosome Philadelphia (Ph). Ā, ko te ira whakakotahi BCR-ABL ka hangaia mā te whakawhiti i waenga i te proto-oncogene ABL (Abelson murine leukemia viral oncogene homolog 1) i te ringa roa o te chromosome 9 (9q34) me te ira breakpoint cluster region (BCR) i te ringa roa o te chromosome 22 (22q11). Ko tōna pūmua whakakotahi i whakakōrerohia e tēnei ira he mahi tyrosine kinase (TK), ā, ka whakahohe i ōna ara tohu o raro (pērā i te RAS, PI3K, me te JAK/STAT) hei whakatairanga i te wehenga pūtau me te aukati i te apoptosis pūtau, ka nui haere ngā pūtau kino, ā, ka puta te CML.
Ko te ira honohono BCR-ABL, he mea nui ki te whanaketanga o te CML, he tohu matua mō te tautuhi mate o te CML. Mā tōna kitenga ka āwhina i te aroturuki i te tūroro'te urupare a te rongoā ki ngā aukati tyrosine kinase (TKI) me te matapae i te hokinga mai o te leukemia, he mea nui ki te whakahaere whai hua i ngā tūroro CML.
BCR-ABL TangataKete Kimi Whakarerekētanga Ira Whakakotahimai i te Macro & Micro-Test mō te kimi kounga o te BCR-ABL i roto i ngā tūroro CML, āwhina i te tautuhi i te CML me te ārahi i ngā maimoatanga haumanu kua arotahihia hei arotau i ngā rautaki rongoā mō te whakahaere tūroro whai hua. Te hononga BCR-ABLe, ekomea nuii roto i te whanaketanga o te CML,hei tohu matua mō te tātaritangaofCMLMā tōna kitenga ka āwhina ki tearoturukitūroro'ste urupare ki ngā aukati tyrosine kinase (TKI)mee tohu ana i te hokinga mai o te leukemia, koia tēneimea nuito whai huaCMLte whakahaere tūroro.
Kete Kimi Whakarerekētanga Ira Whakakotahitanga BCR-ABL Tangata mai i te Macro & Micro-Test mō te kimi kounga o te BCR-ABL i roto i ngā tūroro CML, ngā āwhinaCMLtātaritangamengā kaiārahingā maimoatanga haumanu kua arotahihiatowhakapai akeengā rautaki rongoā mō te whakahaere tūroro whai hua.
WhānuiDārai:I te wā kotahite kimimō3ngā ira honohono noa (P210, P190, P230)mōte whānuitanga o te kapinga mete ārai i ngā take i ngaro;
Teitei o te Tairongo:Ka kitea e te putanga wai ngā ira whakakotahime te LoDo te 1000 kape/mL,me te putanga lyophilizedof 500 ngā tārua/mL;
Tino paiAte tika: Iā-rotowhakahaereme te whākōkī UNG hei ārai i ngā hua teka& ngā mea kino;
Te whakahaere ngāwari me te whai hua:Te mahi ngongo kati,kore utu o ngā huate tukatuka-muri,mete kimii roto60 menetimōngā hua whai kiko, pono hoki;
Ētahi atuNgā Kōwhiringa：Ngā putanga wai me te lyophilized mō ngā kōwhiringa a ngā kiritaki;
Hototahi Whānui:Hototahi ki te nuinga o ngā pūnaha PCR mō te urunga whānui ki te taiwhanga.
WhānuiDārai:I te wā kotahite kimimō3ngā ira honohono noa (P210, P190, P230)mōte whānuitanga o te kapinga mete ārai i ngā take i ngaro;
Teitei o te Tairongo:Ka kitea e te putanga wai ngā ira whakakotahime te LoDo te 1000 kape/mL,me te putanga lyophilizedof 500 ngā tārua/mL;
Tino paiAte tika: Iā-rotowhakahaereme te whākōkī UNG hei ārai i ngā hua teka& ngā mea kino;
Te whakahaere ngāwari me te whai hua:Te mahi ngongo kati,kore utu o ngā huate tukatuka-muri,mete kimii roto60 menetimōngā hua whai kiko, pono hoki;
Ētahi atuNgā Kōwhiringa：Ngā putanga wai me te lyophilized mō ngā kōwhiringa a ngā kiritaki;
Hototahi Whānui:Hototahi ki te nuinga o ngā pūnaha PCR mō te urunga whānui ki te taiwhanga.
Wā tuku: Mei-16-2024