Ko ngā whakarerekētanga pūwāhi i roto i te ira KRAS e pā ana ki te whānuitanga o ngā pukupuku tangata, me ngā reiti whakarerekētanga tata ki te 17%–25% puta noa i ngā momo pukupuku, 15%–30% i roto i te mate pukupuku pūkahukahu, me te 20%–50% i roto i te mate pukupuku koroni. Ka akiakihia e ēnei whakarerekētanga te ātete maimoatanga me te whanaketanga o te pukupuku mā roto i tētahi tikanga matua: ko te pūmua P21 i whakakōrerohia e KRAS ka mahi i raro i te ara tohu EGFR. Kia whakarerekētia te KRAS, ka whakahohe tonu i te tohu o raro, ka kore e whai hua ngā maimoatanga e arohia ana ki te EGFR i runga ake, ā, ka arahi ki te tipu tonu o ngā pūtau kino. Nō reira, ka honoa ngā whakarerekētanga KRAS ki te ātete ki ngā aukati EGFR tyrosine kinase i roto i te mate pukupuku pūkahukahu me ngā maimoatanga paturopi anti-EGFR i roto i te mate pukupuku koroni.

I te tau 2008, i whakatūria e te Whatunga Matepukupuku Whānui ā-Motu (NCCN) he aratohu haumanu e taunaki ana i te whakamātautau ira KRAS mō ngā tūroro katoa e pāngia ana e te matepukupuku koroni kua horapa (mCRC) i mua i te maimoatanga. E whakaatu ana ngā aratohu ko te nuinga o ngā ira KRAS whakahohe ka puta i roto i ngā kōtona 12 me te 13 o te exon 2. Nō reira, he mea nui te kimi ira KRAS tere me te tika hei ārahi i te rongoā haumanu tika.

He aha te mea nui o te whakamātautau KRAS i roto iMetastaticCte rekereke o te wahaCmate pukupuku(mCRC)

Ehara te mate pukupuku repeure (CRC) i te mate kotahi, engari he kohinga o ngā momo ira motuhake. Ko ngā whakarerekētanga KRAS—kei roto i te 40–45% o ngā tūroro CRC—e mahi ana hei pana "kā" tonu, e whakatairanga ana i te tipu o te mate pukupuku ahakoa he tohu o waho. Mō ngā tūroro he mCRC, ko te mana KRAS te mea e whakatau ana i te whai huatanga o ngā paturopi monoclonal anti-EGFR pēnei i a Cetuximab me Panitumumab:

KRAS Momo-Mohoao:Tērā pea ka whai hua ngā tūroro i te maimoatanga anti-EGFR.

KRAS Mutant:Kāore he painga e riro mai i ngā tūroro mai i ēnei rongoā, e tūpono ana hoki ki ngā pānga taha koretake, te pikinga o ngā utu, me te whakaroa i te whai huatanga o te rongoā.

Nō reira, ko te whakamātautau KRAS tika, tairongo hoki te tūāpapa o te whakamahere maimoatanga whaiaro.

Te Wero Kimi: Te Wehewehe i te Tohu Whakarerekētanga Ira

He maha ngā wā kāore i te aro nui ngā tikanga tuku iho ki ngā whakarerekētanga iti-rahi, inā koa i roto i ngā tauira he iti te ihirangi pukupuku, i muri rānei i te tango i te konupūmā. Ko te uauatanga kei te wehewehe i te tohu DNA whakarerekē ngoikore ki tētahi papamuri momo-mohoao teitei—he rite ki te kimi ngira i roto i te puranga tarutaru. Ka taea e ngā hua hē te arahi ki te maimoatanga hē me ngā putanga kino.

Tā Mātou Otinga: I Hangaia kia Tika mō te Kitenga Whakarerekētanga Maia

Ka whakauruhia e tā mātou Kete Kite Mutunga KRAS ngā hangarau matatau hei wikitoria i ēnei herenga, ka tukuna he tino tika me te pono mō te arataki whakaora mCRC.

Te Āhua o te Whakahaere a Tā Mātou Hangarau i te Mahi Tino Pai

• Hangarau ARMS Whakarei (Pūnaha Whakarerekētanga Ārai Whakarei): Hangaia ki runga i te hangarau ARMS, me te whakauru i te hangarau whakarei ake hei whakanui ake i te motuhaketanga o te kitenga.
• Whakarei ake i ngā whākōkī: Ka whakamahi i ngā endonuclease here hei nakunaku i te nuinga o te papamuri momo-mohoao o te ira tangata, ka penapena i ngā momo ira whakarerekē, ā, ka whakarei ake i te taumira kitenga me te whakaiti i te whakanui kore-motuhake nā te papamuri ira teitei.
• Te Ārai i te Mahana: Ka whakauru i ngā kaupae pāmahana motuhake ki roto i te tukanga PCR, ka puta he rerekētanga i waenga i ngā paraime ira whakarerekē me ngā tauira momo-tūroa, ā, ka whakaitihia te papamuri momo-tūroa me te whakapai ake i te taumira kitenga.
• Te Tairongo Nui: Ka kitea tika te iti rawa o te 1% o te DNA whakarerekētanga.
• Tino Tika: Ka whakamahi i ngā paerewa ā-roto me te whākōkī UNG hei ārai i ngā hua pai me ngā hua kino teka.
• Māmā, Tere hoki: Ka oti te whakamātautau i roto i te 120 meneti pea, mā te whakamahi i ngā ngongo tauhohenga e rua hei āwhina i te kimi i ngā whakarerekētanga rerekē e waru, kia puta ai he hua pono, whai kiko hoki.
• Hototahi o ngā Taputapu: Ka urutau ki ngā momo taputapu PCR.

Ka tīmata te rongoā tika mō te mate pukupuku koroni me te tātaritanga ngota tika. Mā te whakamahi i tā mātou Kete Kimi Mutunga KRAS, ka taea e tō taiwhanga te whakaputa hua tino whai hua, ka taea te mahi, ka whakatau tika i te ara maimoatanga a te tūroro.

Whakamanahia tō taiwhanga ki ngā hangarau pono, hou hoki—kia taea ai te tiaki whaiaro.

Whakapā mai: hokohoko@mmtest.Com

Ako atu mō te whakauru i tēnei otinga matatau ki roto i tō tukanga tātaritanga.

#Rekereke #Matepukupuku #DNA #Whakarerekētanga #Tika #Whakaarohia #Maimoatanga #Matepukupuku

Te Wetewete i te Rongoā Tika i roto i te Matepukupuku Korokoro

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