Tangata BCR-ABL Fusion Gene Mutation
ingoa hua
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR )
HWTS-GE016A-Whakatio-maroke-tangata BCR-ABL Fusion Gene ira Mutation Kit Detection (Fluorescence PCR)
Epidemiology
Ko te myelogenousleukemia mau tonu (CML) he mate kawa kino o nga pūtau kakau hematopoietic. Neke atu i te 95% o nga turoro CML e kawe ana i te Philadelphia chromosome (Ph) i roto i o raatau toto. Ko te pathogenesis nui o te CML e whai ake nei: Ko te ira whakakotahitanga BCR-ABL ka hangaia e te whakawhiti i waenga i te abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) i runga i te ringa roa o te chromosome 9 (9q34) me te ira rohe kahui breakpoint (BCR) i te ringa roa o te chromosome (22q121); Ko te pūmua whakakotahitanga e whakawaeheretia ana e tenei ira he mahi tyrosine kinase (TK), me te whakahohe i ona huarahi tohu whakararo (pēnei i te RAS, PI3K, me te JAK/STAT) ki te whakatairanga i te wehenga pūtau me te aukati i te apoptosis pūtau, ka tipu kino nga pūtau, na reira ka puta te CML. Ko te BCR-ABL tetahi o nga tohu tātaritanga nui o CML. Ko te huringa hihiri o tana taumata tuhinga he tohu pono mo te whakatau matapae mo te kanisā, ka taea te whakamahi ki te matapae i te hokinga mai o te reukemia i muri i te maimoatanga.
Hongere
| FAM | BCR-ABL ira whakakotahi |
| VIC/HEX | Mana o roto |
Tawhā Hangarau
| Rokiroki | Wai: ≤-18 ℃ I te pouri |
| Papa-ora | Wai: 9 marama |
| Momo Tauira | Tauira hinu wheua |
| LoD | 1000 kape/ mL |
| Tauwhāiti
| Karekau he tauhohenga whakawhiti me etahi atu ira hanumi TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, me PML-RARa |
| Nga taputapu e tika ana | Whakamahinga Biosystems 7500 Pūnaha PCR Wā-tūturu Whakamahi Biosystems 7500 Pūnaha PCR Wā-tūturu Tere QuantStudio® 5 Pūnaha PCR Wā-tūturu SLAN-96P Pūnaha PCR Wā-tūturu LightCycler®480 Pūnaha PCR Wā-tūturu LineGene 9600 Plus Pūnaha Tirohanga PCR Wā-tūturu MA-6000 Waa-Tuturu Ine Ine Hukarere Ngawha BioRad CFX96 Pūnaha PCR Wā-tūturu BioRad CFX Opus 96 Pūnaha PCR Wā-tūturu |
