Tangata EGFR Gene 29 Mutations

Whakaahuatanga Poto:

Ka whakamahia tenei kete ki te kitea i roto i te in vitro nga momo rerekee noa i roto i nga exons 18-21 o te ira EGFR i roto i nga tauira mai i nga turoro mate pukupuku pūkahukahu kore-iti.


Taipitopito Hua

Tohu Hua

ingoa hua

HWTS-TM001A-Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)

Epidemiology

Ko te mate pukupuku o te pukahukahu te take matua o te mate pukupuku puta noa i te ao, e tino whakararu ana i te hauora o te tangata.Ko te mate pukupuku pūkahukahu kore-iti kei te 80% o nga turoro mate pukupuku pūkahukahu.I tenei wa, ko te EGFR te tino whainga irapoi mo te maimoatanga o te mate pukupuku pukupuku kore-iti.Ka taea e te phosphorylation o EGFR te whakatairanga i te tipu o te pukupuku pukupuku, te rereketanga, te whakaeke, te metastasis, te anti-apoptosis, me te whakatairanga i te angiogenesis pukupuku.Ka taea e te EGFR tyrosine kinase inhibitors (TKI) te aukati i te huarahi tohu tohu EGFR ma te aukati i te autophosphorylation EGFR, na reira ka aukati i te tipu me te rereketanga o nga pūtau pukupuku, te whakatairanga i te apoptosis pūtau pukupuku, te whakaiti i te angiogenesis pukupuku, me etahi atu, kia tutuki ai te maimoatanga mate pukupuku.He maha nga rangahau kua whakaatu ko te kaha o te rongoa o te EGFR-TKI e hono tata ana ki te mana o te ira ira EGFR, a ka taea te aukati i te tipu o nga pūtau puku me te ira ira EGFR.Ko te ira EGFR kei runga i te ringa poto o te chromosome 7 (7p12), he 200Kb te roa, he 28 exons kei roto.Ko te nuinga o te rohe kua whakarereketia kei roto i nga exons 18 ki te 21, ko nga codons 746 ki te 753 te whakakore i te huringa i runga i te exon 19 mo te 45% me te L858R i runga i te exon 21 mo te 40% ki te 45%.Ko nga Aratohu a te NCCN mo te Whakamatau me te Maimoatanga o te Matepukupuku Puku Puku-kore-iti e kii marama ana ko te whakamatautau ira ira EGFR i mua i te whakahaeretanga o te EGFR-TKI.Ka whakamahia tenei kete whakamatautau ki te arahi i te whakahaeretanga o nga raau taero epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), me te whakarato i te kaupapa mo te rongoa whaiaro mo nga turoro he mate pukupuku pūtau kore-iti.Ka whakamahia noa tenei kete mo te kite i nga huringa noa i roto i te ira EGFR i roto i nga turoro me te mate pukupuku pūtau kore-iti.Ko nga hua whakamatautau mo te tohutoro haumanu anake, kaua e whakamahia hei kaupapa mo te maimoatanga takitahi o nga turoro.Me whai whakaaro nga tohunga haumanu ki te ahua o te manawanui, nga tohu rongoa me te maimoatanga Ka whakamahia te tauhohenga me etahi atu tohu whakamatautau taiwhanga me etahi atu mea hei whakatau i nga hua whakamatautau.

Hongere

FAM IC Reaction Buffer, L858R Reaction Buffer, 19del Reaction Buffer, T790M Reaction Buffer, G719X Reaction Buffer, 3Ins20 Reaction Buffer, L861Q Reaction Buffer, S768I Reaction Buffer

Tawhā Hangarau

Rokiroki Wai: ≤-18 ℃ I te pouri;Lyophilized: ≤30 ℃ I te pouri
Papa-ora Wai: 9 marama;Lyophilized: 12 marama
Momo Tauira te kiko pukupuku hou, te waahanga pathological tio, te kiko pathological kua whakauruhia he paraffin, te waahanga ranei, te plasma, te serum ranei
CV <5.0%
LoD te kitenga otinga tauhohenga waikawa nucleic i raro i te papamuri o te 3ng/μL momo mohoao, ka taea te kite i te 1% te reeti rereke
Tauwhāiti Karekau he tauhohenga whakawhiti me te momo mohoao mohoao DNA ira tangata me etahi atu momo mutant
Nga taputapu e tika ana Whakamahinga Biosystems 7500 Pūnaha PCR Wā-tūturuWhakamahi Biosystems 7300 Pūnaha PCR Wā-tūturu

QuantStudio® 5 Pūnaha PCR Wā-tūturu

LightCycler® 480 Pūnaha PCR Wā-tūturu

BioRad CFX96 Pūnaha PCR Wā-tūturu

Rere Mahi

5a96c5434dc358f19d21fe988959493


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