Kete Kimi Ira Tangata EGFR 29 (PCR Fluorescence)-RUO

Kua riro te mate pukupuku pūkahukahu hei tino take o ngā mate pukupuku puta noa i te ao, ā, he tino mōrearea ki te hauora o te tangata. Tata ki te 80%-85% o ngā tūroro mate pukupuku pūkahukahu te mate pukupuku pūkahukahu ehara i te pūtau iti. Ko te EGFR te whāinga ngota nui rawa atu mō te rongoā i te mate pukupuku pūkahukahu ehara i te pūtau iti. Ka taea e te phosphorylation o te EGFR te whakatairanga i te tipu o ngā pūtau pukupuku, te rerekētanga, te whakaekenga, te metastasis, te ārai-apoptosis, me te whakatairanga i te angiogenesis pūkahukahu. Ka taea e ngā aukati tyrosine kinase EGFR (TKI) te aukati i te ara tohu EGFR mā te aukati i te autophosphorylation EGFR, ā, ka aukati i te tipu me te rerekētanga o ngā pūtau pukupuku, ka whakatairanga i te apoptosis pūtau pukupuku, ka whakaiti i te angiogenesis pūkahukahu, me ētahi atu, kia tutuki ai te rongoā arotahi ki te pūkahukahu [1]. He maha ngā rangahau kua whakaatu ko te whai huatanga rongoā o te EGFR-TKI he hononga tata ki te mana o te whakarerekētanga ira EGFR, ā, ka taea te aukati motuhake i te tipu o ngā pūtau pukupuku me te whakarerekētanga ira EGFR [2,3]. Kei te ringa poto o te chromosome 7 (7p12) te ira EGFR, me te roa katoa o te 200Kb, ā, e 28 ngā exon. Ko te rohe whakarerekētanga kei roto i ngā exon 18 ki te 21, ko ngā codon 746 ki te 753 te whakarerekētanga mukunga i runga i te exon 19 mō te 45%, ā, ko te whakarerekētanga L858R i runga i te exon 21 mō te 40% ki te 45% [4]. E kī mārama ana ngā Aratohu NCCN mō te Tātaritanga me te Maimoatanga o te Mate Pukupuku Pūkahukahu Kāore i te Iti, me whakamātautau whakarerekētanga ira EGFR i mua i te whakahaerenga EGFR-TKI. Ka whakamahia tēnei kete whakamātautau hei ārahi i te whakahaerenga o ngā rongoā epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), ā, ka whakarato i te pūtake mō te rongoā whaiaro mō ngā tūroro he mate pukupuku pūkahukahu kāore i te iti. Ka whakamahia anake tēnei kete mō te kimi i ngā whakarerekētanga noa i roto i te ira EGFR i roto i ngā tūroro he mate pukupuku pūkahukahu kāore i te iti. Ko ngā hua whakamātautau he tohutoro haumanu anake, kaua e whakamahia hei pūtake anake mō te maimoatanga takitahi o ngā tūroro. Me whai whakaaro ngā tākuta ki te āhua o te tūroro, ngā tohu rongoā, me te maimoatanga. Ka whakamahia te tauhohenga me ētahi atu tohu whakamātautau taiwhanga me ētahi atu āhuatanga hei aromatawai whānui i ngā hua whakamātautau.