Te ariā o te pukupuku
He rauropi hou te pukupuku i hangaia e te tipu rerekē o ngā pūtau i roto i te tinana, e kitea pinepine ana hei puranga kiko rerekē (puku) i te wāhanga o te tinana. Ko te hanganga pukupuku te hua o te koretake nui o te whakahaere tipu pūtau i raro i te mahi a ngā āhuatanga pukupuku. Ko te tipu rerekē o ngā pūtau e arahi ana ki te hanganga pukupuku ka kiia ko te tipu neoplastic.
Nō te tau 2019, i whakaputahia e Cancer Cell tētahi tuhinga i ngā wā tata nei. I kitea e ngā kairangahau ka taea e te metformin te aukati i te tipu o te pukupuku i te wā nohopuku, ā, i kīia ko te ara PP2A-GSK3β-MCL-1 pea he ūnga hou mō te maimoatanga pukupuku.
Ko te rerekētanga matua i waenga i te pukupuku pai me te pukupuku kino
Puku pai: puhoi te tipu, ka pūkahukahu, ka pupuhi, ka paheke ki te pā, ka mārama te rohe, kāore he horapa ki te tinana, he pai te matapae, he tohu pēhi ā-rohe, kāore he tinana katoa, kāore e mate ai ngā tūroro.
Puku kino (matepukupuku): te tere o te tipu, te horapa nui, te piri ki ngā kiko e karapoti ana, te kore e taea te neke ina pāngia, te kore mārama o te rohe, te ngāwari o te horapa ki te tinana, te ngāwari o te hoki mai i muri i te maimoatanga, te kirika iti, te kore hiahia kai i te wā tōmua, te hekenga o te taumaha, te hiroki kino, te toto totoka me te kirika i te wā tōmuri, me ētahi atu. Ki te kore e rongoatia i te wā tika, ka mate pea.
"Nā te mea he rerekē ngā āhuatanga haumanu o ngā pukupuku pai me ngā pukupuku kino, engari he mea nui ake, he rerekē te āhua o ō rāua mate, nō reira, ina kitea he puku i roto i tō tinana me ngā tohu o runga ake nei, me rapu tohutohu hauora i te wā tika."
Te maimoatanga takitahi o te pukupuku
Kaupapa Ira Tangata me te Kaupapa Ira Matepukupuku o te Ao
Ko te Kaupapa Ira Tangata, i whakarewahia mana i te Hononga o Amerika i te tau 1990, ko te whāinga he wetewete i ngā waehere katoa o te tata ki te 100,000 ira i roto i te tinana tangata, me te tuhi i te whānuitanga o ngā ira tangata.
I te tau 2006, ko te Kaupapa Ira Matepukupuku o te Ao, i whakarewahia ngātahitia e te maha o ngā whenua, tētahi atu rangahau pūtaiao nui i muri i te Kaupapa Ira Tangata.
Ngā raruraru matua i roto i te maimoatanga o te pukupuku
Tātaritanga me te maimoatanga takitahi = Tātaritanga takitahi + rongoā kua tohua
Mō te nuinga o ngā tūroro e pāngia ana e te mate kotahi, ko te tikanga maimoatanga he whakamahi i te rongoā kotahi me te horopeta paerewa, engari ko te mea pono, he rerekē rawa ngā pānga maimoatanga me ngā pānga kino o ia tūroro, ā, i ētahi wā ka mate pea rātou.
Ko ngā āhuatanga o te rongoā arotahi ko te patu tino whiriwhiri i ngā pūtau pukupuku, me te kore e patu, e kore rānei e tino kino ngā pūtau noa, me ngā pānga taha iti noa iho, e whakapai ake ai i te kounga o te oranga me te pānga rongoā o ngā tūroro.
Nā te mea kua hangaia te rongoā arotahi hei whakaeke i ngā ngota arotahi motuhake, he mea tika kia kitea ngā ira pukupuku me te kite mēnā he ūnga ōrite kei ngā tūroro i mua i te tango i ngā rongoā, kia puta ai he pānga whakaora.
Te kimi ira pukupuku
Ko te kimi ira puku he tikanga hei tātari me te raupapa i te DNA/RNA o ngā pūtau puku.
Ko te hiranga o te kimi ira pukupuku he ārahi i te kōwhiringa rongoā mō te rongoā (ngā rongoā kua arotahihia, ngā aukati ārai mate me ētahi atu AIDS hou, ngā maimoatanga tōmuri), me te matapae i te matapae me te hokinga mai o te mate.
Ngā otinga i whakaratohia e Acer Macro & Micro-Test
Kete Kimi Ira Tangata EGFR 29 (PCR Fluorescence）
Whakamahia mō te kimi kounga o ngā whakarerekētanga noa i roto i te exon 18-21 o te ira EGFR i roto i ngā tūroro matepukupuku pūkahukahu tangata ehara i te pūtau iti i roto i te vitro.
1. Mā te whakaurunga o te mana whakahaere kounga tohutoro ā-roto ki roto i te pūnaha ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga whakamātautau.
2. Te aro nui: ka taea te kite pūmau i te tere whakarerekētanga o te 1% i roto i te papamuri o te otinga tauhohenga waikawa karihi momo-mohoao 3ng/μL.
3. Te tino motuhaketanga: kāore he tauhohenga whakawhiti ki ngā hua kitenga o te DNA ira tangata momo-mohoao me ētahi atu momo ira whakarerekē.
Kete Kimi Ira Hurihanga KRAS 8 (PCR Whakapūtanga Hiko)
E waru ngā momo whakarerekētanga ira i roto i ngā kōtona 12 me te 13 o te ira K-ras i whakamahia hei kimi i te DNA i tangohia mai i ngā wāhanga mate tangata kua whakauruhia ki te paraffin i roto i te vitro.
1. Mā te whakaurunga o te mana whakahaere kounga tohutoro ā-roto ki roto i te pūnaha ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga whakamātautau.
2. Te aro nui: ka taea te kite pūmau i te tere whakarerekētanga o te 1% i roto i te papamuri o te otinga tauhohenga waikawa karihi momo-mohoao 3ng/μL.
3. Te tino motuhaketanga: kāore he tauhohenga whakawhiti ki ngā hua kitenga o te DNA ira tangata momo-mohoao me ētahi atu momo ira whakarerekē.
Kete Kimi Whakarerekētanga Ira ROS1 Tangata (PCR Whakapūtanga)
Whakamahia hei kimi kounga i ngā momo whakarerekētanga 14 o te ira whakakotahi ROS1 i roto i ngā tūroro matepukupuku pūkahukahu tangata ehara i te pūtau iti i roto i te vitro.
1. Mā te whakaurunga o te mana whakahaere kounga tohutoro ā-roto ki roto i te pūnaha ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga whakamātautau.
2. Te aro nui: 20 ngā tārua o te whakarerekētanga ira.
3. Te tino motuhaketanga: kāore he tauhohenga whakawhiti ki ngā hua kitenga o te DNA ira tangata momo-mohoao me ētahi atu momo ira whakarerekē.
Kete Kimi Whakarerekētanga Ira EML4-ALK Tangata (PCR Whakapūtanga)
Whakamahia hei kimi kounga i ngā momo whakarerekētanga 12 o te ira whakakotahitanga EML4-ALK i roto i ngā tūroro matepukupuku pūkahukahu tangata ehara i te pūtau iti i roto i te vitro.
1. Mā te whakaurunga o te mana whakahaere kounga tohutoro ā-roto ki roto i te pūnaha ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga whakamātautau.
2. Te aro nui: 20 ngā tārua o te whakarerekētanga ira.
3. Te tino motuhaketanga: kāore he tauhohenga whakawhiti ki ngā hua kitenga o te DNA ira tangata momo-mohoao me ētahi atu momo ira whakarerekē.
Kete Kimi Whakarerekētanga Ira Tangata BRAF V600E (PCR Whakapūtanga Hiko)
Ka whakamahia hei kimi i te whakarerekētanga kounga o te ira BRAF V600E i roto i ngā tauira kiko kua whakauruhia ki te paraffin o te melanoma tangata, te mate pukupuku colorectal, te mate pukupuku tairoi me te mate pukupuku pūkahukahu in vitro.
1. Mā te whakaurunga o te mana whakahaere kounga tohutoro ā-roto ki roto i te pūnaha ka taea te aroturuki whānui i te tukanga whakamātautau me te whakarite i te kounga whakamātautau.
2. Te aro nui: ka taea te kite pūmau i te tere whakarerekētanga o te 1% i roto i te papamuri o te otinga tauhohenga waikawa karihi momo-mohoao 3ng/μL.
3. Te tino motuhaketanga: kāore he tauhohenga whakawhiti ki ngā hua kitenga o te DNA ira tangata momo-mohoao me ētahi atu momo ira whakarerekē.
| Tau Nama | Ingoa Hua | Whakatakotoranga |
| HWTS-TM006 | Kete Kimi Whakarerekētanga Ira EML4-ALK Tangata (PCR Whakapūtanga) | 20 ngā whakamātautau/kete 50 ngā whakamātautau/kete |
| HWTS-TM007 | Kete Kimi Whakarerekētanga Ira Tangata BRAF V600E (PCR Whakapūtanga Hiko) | 24 ngā whakamātautau/kete 48 ngā whakamātautau/kete |
| HWTS-TM009 | Kete Kimi Whakarerekētanga Ira ROS1 Tangata (PCR Whakapūtanga) | 20 ngā whakamātautau/kete 50 ngā whakamātautau/kete |
| HWTS-TM012 | Kete Kimi Ira Tangata EGFR 29 (PCR Fluorescence） | 16 ngā whakamātautau/kete 32 ngā whakamātautau/kete |
| HWTS-TM014 | Kete Kimi Ira Hurihanga KRAS 8 (PCR Whakapūtanga Hiko) | 24 ngā whakamātautau/kete 48 ngā whakamātautau/kete |
| HWTS-TM016 | Kete Kimi Whakarerekētanga Ira Whakakotahitanga TEL-AML1 Tangata (PCR Whakapūtanga) | 24 ngā whakamātautau/kete |
| HWTS-GE010 | Kete Kimi Whakarerekētanga Ira Whakakotahi BCR-ABL Tangata (PCR Whakapūtanga) | 24 ngā whakamātautau/kete |
Wā tuku: 17 Paenga-whāwhā 2024