Tangata CYP2C9 me VKORC1 Gene Polymorphism

Whakaahuatanga Poto:

E tika ana tenei kete ki te rapunga kounga in vitro o te polymorphism o CYP2C9*3 (rs1057910, 1075A>C) me VKORC1 (rs9923231, -1639G>A) i roto i te DNA genomic o nga tauira toto katoa o te tangata.


Taipitopito Hua

Tohu Hua

ingoa hua

HWTS-GE014A-Human CYP2C9 me VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)

Tiwhikete

CE/TFDA

Epidemiology

Ko te Warfarin he anticoagulant waha e whakamahia nuitia ana i roto i nga mahi haumanu i tenei wa, ko te tikanga mo te aukati me te maimoatanga o nga mate thromboembolic.Heoi, he iti noa te matapihi maimoatanga o te warfarin, he rereke te rereke i waenga i nga iwi me nga tangata takitahi.Kua tohuhia e nga tatauranga ko te rereketanga o te horopeta pumau i roto i nga taangata rereke ka neke atu i te 20 nga wa.Ko te toto tauhohenga kino ka puta ki te 15.2% o nga turoro e tango ana i te warfarin ia tau, ko te 3.5% o enei ka puta he toto mate.Kua whakaatuhia e nga rangahau Pharmacogenomic ko te polymorphism ira o te whaawha whainga VKORC1 me te CYP2C9 o te warfarin he take nui e pa ana ki te rereketanga o te horopeta o te warfarin.Ko te Warfarin he aukati motuhake o te huaora K epoxide reductase (VKORC1), na reira ka aukati i te whakahiatotanga tauwehe kawa e uru ana ki te huaora K me te whakarato anticoagulation.He maha nga rangahau kua tohu ko te polymorphism ira o te kaiwhakatairanga VKORC1 te mea tino nui e pa ana ki te iwi me nga rereketanga takitahi i roto i te horopeta e hiahiatia ana o te warfarin.Ko te Warfarin ka whakakorikorihia e te CYP2C9, a ko ona mutants he tino puhoi te paopaotanga o te warfarin.Ko nga tangata takitahi e whakamahi ana i te warfarin he nui ake te mate (e rua ki te toru nga wa teitei ake) o te whakaheke toto i te timatanga o te whakamahinga.

Hongere

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Tawhā Hangarau

Rokiroki Wai: ≤-18 ℃
Papa-ora 12 marama
Momo Tauira Te toto anticoagulated EDTA hou
CV ≤5.0%
LoD 1.0ng/μL
Tauwhāiti Karekau he tauhohenga whakawhiti me etahi atu raupapa tino rite o te ira tangata (ira CYP2C19 tangata, ira RPN2 tangata);te whakarereketanga o CYP2C9*13 me VKORC1 (3730G>A) i waho o te awhe kitenga o tenei kete
Nga taputapu e tika ana Whakamahinga Biosystems 7500 Pūnaha PCR Wā-tūturu

Whakamahi Biosystems 7500 Pūnaha PCR Wā-tūturu Tere

QuantStudio®5 Pūnaha PCR Wā-tūturu

SLAN-96P Pūnaha PCR Wā-tūturu

LightCycler®480 Pūnaha PCR Wā-tūturu

LineGene 9600 Plus Pūnaha Tirohanga PCR Wā-tūturu

MA-6000 Waa-Tuturu Ine Ine Hukarere Ngawha

BioRad CFX96 Pūnaha PCR Wā-tūturu

BioRad CFX Opus 96 Pūnaha PCR Wā-tūturu

Rere Mahi

Reagent tangohanga Manakohia: Tohutono & Mokoiti-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) me te Macro & Micro-Test Automatic Nucleic Acid Extractor(HWTS- 3006).


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